Kemampuan Aktivitas Dan Fungsi Kognitif Pasien Kanker Payudara Yang Mendapat Kemoterapi
Keywords:
aktivitas, kanker payudara, kemoterapi, kognitif
Abstract
Kemampuan aktivitas fisik dan fungsi kognitif pada kanker payudara sering dilaporkan berubah akibat kemoterapi. Tujuannya adalah untuk menilai korelasi antara kemampuan aktivitas fisik dan fungsi kognitif pada pasien kanker payudara yang menjalani kemoterapi. Metode studi cross-sectional di dilaksanakan pada Poliklinik Bedah Onkologi Rumah Sakit Umum Sanglah, Bali pada bulan September - Oktober 2019. Sebanyak 53 responden mengisi dua kuisioner, dengan kriteria inklusi kanker payudara tanpa tahap metastasis dan telah menjalani kemoterapi. Kriteria eksklusi tidak dapat membaca dan menulis, gangguan mental, keadaan sadar menurun, dan cacat motorik sejak awal. Penelitian ini menemukan korelasi yang tidak signifikan secara statistik antara kemampuan aktifitas fisik dan fungsi kognitif pada pasien kanker payudara yang mendapat kemoterapi dengan nilai korelasi (p> 0,005) antara lima komponen dalam aktivitas dan empat komponen fungsi kognitif yang terkait dengan kualitas hidup. Simpulan penelitian bahwa tidak terdapat korelasi antara kemampuan aktivitas fiisk dengan fungsi kognitif. Studi di masa depan perlu menggunakan pendekatan dan pertimbangan yang mungkin dikembangkan dengan sample lebih besar dan kombinasi menggunakan instrumen objektif pada penelitian.
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References
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Baumann, F. T., Zopf, E. M., Nykamp, E., Kraut, L., le, K. S., Elter, T., . . . Bloch, W. (2011). Physical activity for patients undergoing an allogeneic hematopoietic stem cell transplantation: benefits of a moderate exercise intervention. European Journal of Haematology, 87, 148–156. doi: doi:10.1111/j.1600-0609.2011.01640.x
Bernstein LJ, McCreath GA, Komeylian Z, Rich JB. Cognitive Impairment in Breast Cancer Survivors Treated with Chemotherapy Depends on Control Group Type and Cognitive Domains Assessed: A Multilevel Meta-analysis. Neuroscience and Biobehavioral Reviews. 2017.
Chang, L., Weiner, L. S., Hartman, S. J., Horvath, S., Jeste, D., Mischel, P. S., & Kado, D. M. (2019). Breast cancer treatment and its effects on aging. Journal of Geriatric Oncology, 10(2), 346–355. https://doi.org/10.1016/j.jgo.2018.07.010
Chinapaw, M. J. M., Slootmaker, S. M., Schuit, A. J., Van Zuidam, M., & Van Mechelen, W. (2009). Reliability and validity of the activity questionnaire for adults and adolescents (AQuAA). BMC Medical Research Methodology, 9(1), 1–8. https://doi.org/10.1186/1471-2288-9-58
Edelstein, K., & Bernstein, L. J. (2014). Cognitive dysfunction after chemotherapy for breast cancer. Journal of the International Neuropsychological Society, 20(4), 351–356. https://doi.org/10.1017/S1355617714000149
Hess, L. M., Huang, H. Q., Hanlon, A. L., Robinson, W. R., Johnson, R., Chambers, S. K., … Alberts, D. S. (2015). Cognitive function during and six months following chemotherapy for front-line treatment of ovarian, primary peritoneal or fallopian tube cancer: An NRG oncology/gynecologic oncology group study. Gynecologic Oncology, 139(3), 541–545. https://doi.org/10.1016/j.ygyno.2015.10.003
Hwang, S. Y., Chang, S. J., & Park, B. W. (2013). Does chemotherapy really affect the quality of life of women with breast cancer? Journal of Breast Cancer, 16(2), 229–235. https://doi.org/10.4048/jbc.2013.16.2.229
Jim, H. S. L., Phillips, K. M., Chait, S., Faul, L. A., Popa, M. A., Lee, Y. H., … Small, B. J. (2012). Meta-analysis of cognitive functioning in breast cancer survivors previously treated with standard-dose chemotherapy. Journal of Clinical Oncology, 30(29), 3578–3587. https://doi.org/10.1200/JCO.2011.39.5640
Joshi, G., Aluise, C. D., Cole, M. P., Sultana, R., Pierce, W. M., Vore, M., … Butterfield, D. A. (2010). Alterations in brain antioxidant enzymes and redox proteomic identification of oxidized brain proteins induced by the anti-cancer drug adriamycin: implications for oxidative stress-mediated chemobrain. Neuroscience, 166(3), 796–807. https://doi.org/10.1016/j.neuroscience.2010.01.021
Lippi, G., Mattiuzzi, C., & Sanchis-Gomar, F. (2019). Updated overview on interplay between physical exercise, neurotrophins, and cognitive function in humans. Journal of Sport and Health Science, 00. https://doi.org/10.1016/j.jshs.2019.07.012
Mikkelsen, M. K., Nielsen, D. L., Vinther, A., Lund, C. M., & Jarden, M. (2019). Attitudes towards physical activity and exercise in older patients with advanced cancer during oncological treatment – A qualitative interview study. European Journal of Oncology Nursing, 41(December 2018), 16–23. https://doi.org/10.1016/j.ejon.2019.04.005
Payne Y. 2009. Breast Cancer In: Newton S, Hickey M, Marrs J, editors. Mosby's Oncology Nursing Advisor A Comprehensive Guide to Clinical Practice Missouri, USA: Mosby Elsevier; p. 35-40
Rosser, M., & Walsh, H. (2014). Fundamentals of Palliative Care for Student Nurses. New York: John Wiley & Sons.
Spartano, N. L., Demissie, S., Himali, J. J., Dukes, K. A., Murabito, J. M., Vasan, R. S., … Seshadri, S. (2019). Accelerometer-determined physical activity and cognitive function in middle-aged and older adults from two generations of the Framingham Heart Study. Alzheimer’s and Dementia: Translational Research and Clinical Interventions, 5, 618–626. https://doi.org/10.1016/j.trci.2019.08.007
Tachi, T., Teramachi, H., Tanaka, K., Asano, S., Osawa, T., Kawashima, A., … Goto, C. (2015). The impact of outpatient chemotherapy-related adverse events on the quality of life of breast cancer patients. PLoS ONE, 10(4), 1–16. https://doi.org/10.1371/journal.pone.0124169
The Global Cancer Observatory. (2019). Country-specific (Indonesia), Incidence Method, National Country-specific, Mortality. Globocan-WHO, 256, 1–2. Retrieved from https://gco.iarc.fr/today/data/factsheets/populations/360-indonesia-fact-sheets.pdf
Turnip, M., Keliat, B. A., & Putri, Y. S. E. (2013). Fenomena konflik, ansietas, dan depresi pda klien kanker setelah didiagnosa satu tahun dan mendapat terapi di rumah sakit umum. Jurnal Ners, 10(2), 242–249. Retrieved from https://e-journal.unair.ac.id/JNERS/article/view/30/1075
Van Hoye, A., Omorou, Y., Rotonda, C., Gendarme, S., Tarquinio, C., Houtmann, B., … Martin-Krumm, C. (2019). Psychological and social determinants of physical activity from diagnosis to remission among French cancer patients (PERTINENCE): Protocol for a mixed-method study. BMC Public Health, 19(1), 1–8. https://doi.org/10.1186/s12889-019-7368-y
Wagner, L., Sweet, J., Lai, J., & Cella, D. (2009). Measuring patient self-reported cognitive function: Development of the functional assessment of cancer therapy-cognitive function instrument. The Journal of Supportive Oncology, 7(6), W32–W39. https://doi.org/10.1002/phar.1467
WHO. (2018). Cancer. Retrieved October 10, 2019, from http://www.who.int/cancer/en/
Wulandari, S. K., Hermayanti, Y., Yamin, A., & Efendi, F. (2017). Family Process with Breast Cancer Patient in Indonesia. Jurnal Ners, 12(2), 180. https://doi.org/10.20473/jn.v12i2.5970
Xiao, C., Miller, A. H., Felger, J., Mister, D., Liu, T., & Torres, M. A. (2016). A prospective study of quality of life in breast cancer patients undergoing radiation therapy. Advances in Radiation Oncology, 1(1), 10–16. https://doi.org/10.1016/j.adro.2016.01.003
Published
2020-04-30
How to Cite
Wulandari, S. K., & Wahyunadi, N. M. D. (2020). Kemampuan Aktivitas Dan Fungsi Kognitif Pasien Kanker Payudara Yang Mendapat Kemoterapi. Jurnal Keperawatan BSI, 8(1), 1-7. Retrieved from http://ejurnal.ars.ac.id/index.php/keperawatan/article/view/168
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